(2015). Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 3997–4000). IEEE. https://doi.org/10.1109/embc.2015.7319270
Περίληψη
In the road for network medicine the newly emerged systems-level subpathway-based analysis methods offer new disease genes, drug targets and network-based biomarkers. In parallel, paired miRNA/mRNA expression data enable simultaneously monitoring of the micronome effect upon the signaling pathways. Towards this orientation, we present a methodological pipeline for the identification of differentially expressed subpathways along with their miRNA regulators by using KEGG signaling pathway maps, miRNA-target interactions and expression profiles from paired miRNA/mRNA experiments. Our pipeline offered new biological insights on a real application of paired miRNA/mRNA expression profiles with respect to the dynamic changes from colostrum to mature milk whey; several literature supported genes and miRNAs were recontextualized through miRNA-mediated differentially expressed subpathways.
- DOI
- 10.1109/embc.2015.7319270
- Τύπος
- Άρθρο σε Πρακτικά Συνεδρίου
- Έτος
- 2015
Σύνδεσμοι
BibTeX
@inproceedings{vrahatis2015identifying,
title = {Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology},
author = {Aristidis G. Vrahatis and Georgios N. Dimitrakopoulos and Athanasios K. Tsakalidis and Anastasios Bezerianos},
url = {https://doi.org/10.1109/embc.2015.7319270},
doi = {10.1109/embc.2015.7319270},
year = {2015},
date = {2015-01-01},
booktitle = {2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)},
volume = {8},
pages = {3997–4000},
publisher = {IEEE},
abstract = {In the road for network medicine the newly emerged systems-level subpathway-based analysis methods offer new disease genes, drug targets and network-based biomarkers. In parallel, paired miRNA/mRNA expression data enable simultaneously monitoring of the micronome effect upon the signaling pathways. Towards this orientation, we present a methodological pipeline for the identification of differentially expressed subpathways along with their miRNA regulators by using KEGG signaling pathway maps, miRNA-target interactions and expression profiles from paired miRNA/mRNA experiments. Our pipeline offered new biological insights on a real application of paired miRNA/mRNA expression profiles with respect to the dynamic changes from colostrum to mature milk whey; several literature supported genes and miRNAs were recontextualized through miRNA-mediated differentially expressed subpathways.},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}